Clinical Uses

The important functional role in homeostatic and disease conditions makes the use adrenomedullin crucial in routine clinical use. A more accurate risk assessment with MR-proADM can reduce patient hospitalization, increase patient out-treatment, and provide an early warning of the development of additional, adverse complications.


MR-proADM: Used in a wide range of clinical applications

Cardiac Disorders gif animationCardiac Disorders

  • Improved diagnostic descrimiation and reclassification of patients with acute coronary syndrome
  • Outperforms BNP and NT-BNP in predicting mortality in ED patients with dyspnea after 30 days

ADM levels

↑ Contractility
↑ Vasodilation
↓ Blood pressure

Kidney Disease gif animationKidney Disease

  • Greater or comparable precision when determining risk of CKD progression compared to standard GFR measurements
  • Fluctuations in creatinine levels due to lifestyle, race and antibiotic use might not reflect true changes in GFR, whereas MR-proADM levels more accurately determine progression of CKD

ADM levels

↑ Sodium excretion
↑ Urine volume
↑ Renal blood flow
↓ Synthesis of aldosterone

Lower Respiratory Tract Infections gif animationLower Respiratory Tract Infections

  • Optimize identification of individuals with a high risk of complications
  • Accurately determine the most appropriate site of treatment and reduce overall length of stay
  • Safely increase out-patient treatment through enhanced discharge management
  • Accurately predict short- and long-term mortality

ADM levels

↓ Pulmonery hypertension
↓ Synthesis of ET-1 and vasoprotective NO

Non-specific complaints gif animationNon-specific complaints

  • Significantly reduce evaluation and diagnostic work-up time for elderly patients
  • Improve workflow in the ED through safe and rapid triage
  • Enhance patient reclassification based on individual risk
  • Safely increase patient discharge, reduce admissions and decrease patient time in the ED

sepsis gif animationSepsis

  • Plays a key role in the hyperdynamic and immunosuppressive phases
  • Increased levels in accordance with severity of disease
  • Fastest rise in concentration in response to bacterial infection
  • Stratifies patients at a high risk of complications and with a poor prognosis for alternative treatment

thermo scientific applied biosystems invitrogen fisher scientific unity lab service