Infection Development After Acute Stroke Trauma

Infection development is one of the most frequent complications following an acute stroke, with an estimated prevalence of 30% Ref-1 due to the onset of immunosuppression following central nervous system injuries. Earlier and more accurate biomarkers are required to predict the development of post-stroke infections Ref-2 in order to initiate earlier and more appropriate treatment strategies. Indeed, approximately one half of cases of stroke associated infection occur within the first 48 hours after stroke onset Ref-3, which is in contrast to that found following burn injuries.

In a recent study by Bustamante et al. (2017), MR-proADM levels were independently associated with infection development within the first 6 hours following the onset of an acute ischemic stroke, with an odds ratio of 3.63 [1.16 - 11.33].

Early biomarkers of infection development, such as MR-proADM represent a unique opportunity for the initiation of an early directed treatment in order to prevent the consequences of post-stroke infection.Ref-4

References Infection development after acute stroke trauma

Ref-1: Westendorp WF, Nederkoorn PJ, Vermeij JD, Dijkgraaf MG, van de Beek D. Post-stroke infection: a systematic review and meta-analysis. BMC Neurol. 2011;11:110.

Ref-2: Smith CJ, Kishore AK, Vail A, et al. Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group. Stroke. 2015;46(8):2335-2340

Ref-3: Finlayson O, Kapral M, Hall R, et al. Risk factors, inpatient care, and outcomes of pneumonia after ischemic stroke. Neurology. 2011;77(14):1338-1345.

Ref-4: Bustamante A, Garcia-Berrocoso T, Penalba A, et al. Sepsis biomarkers reprofiling to predict stroke-associated infections. J Neuroimmunol. 2017;312:19-23.

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